Tel. 514 398-1398 – Email: email@example.com
GPCR and G protein signalling in the cardiovascular system; drug development and design of screening assays for molecular targets.; allosteric regulation of cellular signalling.
Terry Hébert is Associate Professor in Pharmacology and Therapeutics at McGill University. He came to McGill in September 2005 after having spent nine years at the Montréal Heart Institute (a teaching hospital at the Université de Montréal). He is originally from southwestern Ontario (Windsor) and obtained my Ph.D. at the University of Toronto. He is a recipient of a Chercheur National Award from FRSQ (2008-2012) and the 2008 John J. Day Award from the Heart and Stroke Foundation of Canada.
Research Dr. Hébert his lab is centered broadly around the theme of G protein-coupled signal transduction systems. These signalling systems are activated by agonists that bind to G protein-coupled receptors (GPCRs) leading to the regulation of effector proteins (e.g. enzymes and ion channels) by a transducer. We are interested in 1) basic mechanisms of how these signalling systems are wired, 2) novel signalling complexes and pathways associated with alternative subcellular localization of GPCRs and 3) the roles that these architectural features of signalling complex design might play in cardiac disease with a particular emphasis on congenital heart disease. More recently, Prof. Hébert and his group have also become interested in how novel allosteric regulators of these receptors might be developed and tested, here with a focus on inflammatory mediators, their receptors and their roles in health and disease. He has also been investigating basic mechanisms of GPCR regulation, developing functional assays amenable to scaling up and for use as screens for novel modulators of the interactions within GPCR signalling complexes. All of the projects are currently funded. Visit the Lab website.